Inactivation of Poliomyelitis Virus in Vitro by Crystalline Vitamin C (ascorbic Acid)
نویسنده
چکیده
The experimental evidence presented in this paper shows that multiple paralytic doses of poliomyelitis virus, when mixed with very small amounts of crystalline vitamin C (ascorbic acid), are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys.
منابع مشابه
A Further Contribution to Vitamin C Therapy in Experimental Poliomyelitis
1. Multiple paralytic doses of poliomyelitis virus (RMV strain), when brought together with small amounts of synthetic ascorbic acid in vitro, are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys. 2. Vitamin C administration to monkeys infected intranasally with the RMV strain produces results which differ in accordance with the technique emp...
متن کاملA FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS* BY CLAUS W, JUNGEBLUT, M.D. (From the Department of Bacteriology, College of Physicians and Surgeons, Columbia
In previous publications experimental evidence has been adduced to show that vitamin C (l-ascorbic acid) may play an important part in enhancing resistance to poliomyelitic infection in the monkey. Not only could we demonstrate that ascorbic acid possesses powerful antiviral properties in vitro (1), but the administration of this substance to monkeys infected intracerebraUy with the Aycock stra...
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A sensitive procedure for determining total vitamin C (ascorbic acid + dehydrate ascorbic Acid) in a blood drop from a finger prick, before and after the adminis- tration of a vitamin C tablet is described. Analysis was carried out by high per- formance liquid chromatography with electrochemical detection (HPLC/EC). Measurements were taken one hour, two hours and six hours after the adm...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 62 شماره
صفحات -
تاریخ انتشار 2003